Biological membranes

Biological membranes are a fascinating medium, participating in virtually every biological process. We are interested in interactions of multiple proteins and nanoobjects with model cell systems, and subsequent membrane-mediated phenomena.

Thus far we have shown how viruses or nanoparticles can self-assemble into a variety of beautiful and functional patterns when adhering to biological membranes. Furthermore, we found that these particles can induce long tubular protrusions in the membrane, which is a novel route for entry into cell membranes, and points to an unexplored pathway of viral infection.

Left panel: Linear aggregation of spherical particles on a membrane vesicle. Right panel: Tabulation of membrane vesicle induced by nano-objects.

Left panel: Linear aggregation of spherical particles on a membrane vesicle. Right panel: Tubulation of membrane vesicle induced by nano-objects.

 

  1. M. Šimunović, A. Šarić, M. Henderson, K. Y. C. Lee and G. A. Voth, Lipid membrane mediates long-range interactions between linear aggregates of membrane-curving proteins, Submitted (2016).
  2. C. van der Wel, A. Vahid, A. Šarić, T. Idema, D. Heinrich and D. J. Kraft, Lipid membrane-mediated attraction between curvature inducing object, Scientific Reports 6, 32825 (2016).
  3. S. J. Bachmann, J. Kotar, L. Parolini, A. Šarić, P. Cicuta, L. Di Michele and B. M. Mognetti, Melting transition in lipid vesicles functionalised by mobile DNA linkers, Soft Matter 12, 7804 (2016).
  4. A. Šarić and A. Cacciuto. Self-assembly of nanoparticles adsorbed on fluid and elastic membranes. Soft Matter 9, 6677 (2013). (Review article.)
  5. A. Šarić and A. Cacciuto. Mechanism of membrane tube formation induced by adhering nanocomponents. Phys. Rev. Lett. 109, 188101 (2012). (Cover paper of the weekly issue. Highlighted in Physics Synopsis.)
  6. A. Šarić and A. Cacciuto. Fluid membranes can drive linear aggregation of adsorbed spherical nanoparticles. Phys. Rev. Lett. 108, 118101 (2012). (Editor’s suggestion.)